• The Multiple Myeloma Set Domain (Mmset) Protein epub

    The Multiple Myeloma Set Domain (Mmset) ProteinThe Multiple Myeloma Set Domain (Mmset) Protein epub
    The Multiple Myeloma Set Domain (Mmset) Protein




    The Multiple Myeloma Set Domain (Mmset) Protein epub. Multiple myeloma SET domain-containing protein. Short name: MMSET A chromosomal aberration involving NSD2 is a cause of multiple myeloma tumors. MMSET(Multiple Myeloma SET domain). In normal tissues, MMSET has a complex pattern of expression with a short form (647 amino acids [aa]) containing an HMG box and hath region, and an alternatively spliced long form (1365 aa) containing the HMG box and hathregion plus 4 PHD fingers and a SET domain. Although t(4;14) translocation results in The NSD2/MMSET (Multiple Myeloma Set Domain) gene was identified in the the histone methyltransferase activity of the MMSET protein that might represent The multiple myeloma SET domain (MMSET) protein is overexpressed in multiple myeloma (MM) patients with the translocation t(4;14). Although studies have shown the involvement of MMSET/Wolf-Hirschhorn syndrome candidate 1 in development, its mode of action in the pathogenesis of MM is largely unknown. Conserved domain architecture analysis indicated that MMSET is a multidomain protein containing a set domain (determining protein lysine methyltransferase activity), 2 PWWP (named for a conserved Pro-Trp-Trp-Pro motif) domains, a HMG (high mobility group) box, and To date, these proteins have proven intractable to small molecule inhibition. Here, we the structure of the mutant MMSET SET domain at 2.1 resolution. And regulates GLO1 expression in t(4;14) multiple myeloma cells. NUCLEAR RECEPTOR-BINDING SET DOMAIN PROTEIN 2; NSD2. Alternative titles MULTIPLE MYELOMA SET DOMAIN; MMSET. HGNC Approved Gene SRP0175 Sigma-Aldrich NSD2 catalytic domain Active human recombinant, expressed in E. Coli, 70% (SDS-PAGE).Synonym: MMSET, Multiple myeloma SET domain-containing protein, Nuclear SET domain-containing protein 2, REIIBP, Wolf-Hirschhorn syndrome candidate 1 The Multiple Myeloma SET Domain (MMSET) protein is a histone Neoplasia (4217 articles) Articles on similar topics can be found in the following Blood collections As a consequence of the translocation, two genes are aberrantly expressed, the fibroblast growth factor receptor 3 (FGFR3) and a multiple myeloma SET domain containing protein, MMSET (WHSC1/NSD2), both of which have potential oncogenic activity. 1 Importantly, FGFR3 shows only weak transforming activity and is eventually lost in 30% of patients The top ranked gene, multiple myeloma SET domain (MMSET) showed increased expression in PCa cell lines (22Rv1 and DU145) when compared to the benign prostate epithelium derived cell line RWPE 1, and its expression was decreased upon metformin treatment. SiRNA mediated knockdown of MMSET showed decreased cellular migration and invasion As a consequence of the translocation, two genes are aberrantly expressed: the fibroblast growth factor receptor 3 (FGFR3) and a multiple myeloma SET domain containing protein, MMSET (WHSC1/NSD2), both of which have potential oncogenic activity. 60 Importantly, FGFR3 shows only weak transforming activity and is eventually lost in 30% of Putative MMSET target genes have been previously identified transiently transfecting MMSET cDNA into nonmyeloma cell lines and comparing microarray gene expression profiles between t(4;14)+ and t(4;14) myeloma cases. 24,25,26 27 The latter approach is likely to miss genes such as CD56, which are commonly expressed in both t(4;14)+ and t(4;14) cases, whereas the former approach does not Sep 01, 2019 The histone methyltransferase multiple myeloma SET domain protein (MMSET/WHSC1) is highly expressed in diverse tumor types, and its expression appears to be involved in cell proliferation. In this study, we report that MMSET interacts with and methylates Aurora kinase A (AURKA). MMSET, identified its fusion to the IgH locus in t(4;14) associated multiple myeloma, posses domains found within chromatin regulators including the SET domain. MMSET protein is overexpressed and tighly associated with chromatin in myeloma cell lines carrying t(4;14). Request PDF on ResearchGate | A molecular study of the t(4;14) in multiple myeloma | The t(4;14) translocation is found in approximately 10% of myeloma patients and results in the deregulation of MMSET has recently been shown to have histone methyltransferase activity, of the histone methyltransferase containing SET domain of MMSET constitutes a suggested that it binds to proteins involved in postsplicing intron complexes. Smoldering Multiple Myeloma: Dangerous Precursor: Treatment or Prevention? Multiple myeloma (MM) is a malignancy of plasma cells that not only The Ras/MAPK pathway consists of the Ras proteins, a family of small of the histone methyl transferase Multiple Myeloma SET Domain (MMSET) is One such regulator is MMSET (multiple myeloma SET domain) protein, a histone methyltransferase, that is rearranged and joined with the immunoglobulin locus associated with t(4:14) due to aberrant class switch DNA recombination in approximately 20% of multiple myeloma cases and is associated with particularly poor prognosis. Anti-NSD2 Antibody; Synonym: Nuclear SET domain-containing protein 2, NSD2, NSD2, Multiple myeloma SET domain-containing protein, MMSET, Protein Sinónimos:KMT3G, MMSET, multiple myeloma SET domain containing protein; Símbolos y nombres anteriores:WHSC1, Wolf-Hirschhorn syndrome candidate Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain LEM-06 Implication for Epigenetic Cancer Therapies. Journal of Cancer Prevention 2015;20:113-20. Published online June 30, 2015 Multiple myeloma SET domain (MMSET)/nuclear receptor binding SET domain 2 Purpose: The poor prognosis of multiple myeloma with t(4;14) is driven the fusion of genes encoding multiple myeloma SET domain ( MMSET ) and immunoglobulin heavy chain. Specific genes affected MMSET and their clinical implications in non- MMSET myeloma remain undetermined. Experimental Design: We obtained gene expression profiles of 1,032 newly diagnosed myeloma Multiple myeloma SET domain-containing protein (MMSET, a.k.a. WHSC1, NSD2) is a histone methyltransferase that is frequently WHSC1 protein; nuclear receptor binding SET domain protein 2 Whsc1; Nsd2; MMSET; Whsc1l; AW555663; mKIAA1090; 5830445G22Rik; NSD2; Multiple myeloma SET domain-containing protein; Nuclear SET Nuclear SET Domain-Containing Protein 2, Multiple Myeloma SET Domain Containing Protein MMSET, Probable Histone-Lysine N-Methyltransferase NSD2.





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